In recent years, epizooties (localized outbreaks) of infectious diseases in farmed L. vannamei have caused massive economic losses in China. SHIV was first detected and identified in samples of pond-farmed L. vannamei (2 to 3 cm) collected from a farm in Zhejiang Province, China, in December 2014. Affected animals experienced massive die-offs and exhibited hepatopancreatic atrophy with fading color, empty stomach and guts and soft shells. Results of testing with polymerase chain reaction (PCR) techniques showed that samples were negative for various known shrimp viruses, including WSSV, IHHNV, VPAHPND, YHV and TSV11.